The Os head south of the river to Charlton Athletic on August 5,
The first game at Brisbane Road will see Portsmouth the visitors one week later before they go back on the road, heading to Wycombe Wanderers and Blackpool.
Cambridge United at home on the bank holiday weekend rounds off the first month.
Bolton Wanderers away starts the festive period on December 23 with two home games after Christmas, the return matches with Charlton and Wycombe.
New Year’s Day takes them to Cambridge.
The Easter weekend has Lincoln City away on Good Friday with Peterborough United at home on Easter Monday.
The season ends with a trip to Shrewsbury Town.
EFL League One 2023-2024 – Leyton Orient fixtures in full
August
5.Charlton Athletic (a)
12.Portsmouth (h)
15.Wycombe Wanderers (a)
19.Blackpool (a)
26.Cambridge United (h)
September
2.Stevenage (h)
9.Exeter City (a)
16.Peterborough United (a)
23.Shrewsbury Town (h)
30.Fleetwood Town (a)
October
3.Lincoln City (h)
7.Reading (h)
14.Carlisle United (a)
21.Barnsley (h)
24.Northampton Town (a)
28.Burton Albion (a)
November
11.Oxford United (h)
18.Port Vale (a)
25.Wigan Athletic (h)
28.Bristol Rovers (a)
December
9.Derby County (h)
16.Cheltenham Town (a)
23.Bolton Wanderers (a)
26.Charlton Athletic (h)
29.Wycombe Wanderers (h)
January
1.Cambridge United (a)
6.Blackpool (h)
13.Portsmouth (a)
20.Bolton Wanderers (h)
27.Reading (a)
February
3.Carlisle United (h)
10.Barnsley (a)
13.Northampton Town (h)
17.Burton Albion (h)
24.Oxford United (a)
March
2.Bristol Rovers (h)
9.Wigan Athletic (a)
12.Port Vale (h)
16.Stevenage (a)
23.Exter City (h)
29.Lincoln City (a)
April
1.Peterborough United (h)
6.Cheltenham Town (h)
13.Derby County (a)
20.Fleetwood Town (h)
27.Shrewsbury Town (a)